¶ Monoamine oxidase inhibitors (MAOIs)
Monoamine oxidase inhibitors (also called MAO inhibitors or MAOIs) block the actions of monoamine oxidase enzymes. Monoamine oxidase enzymes are responsible for breaking down neurotransmitters such as dopamine, norepinephrine, and serotonin in the brain.
¶ Contents
- 1 Effectiveness
- 2 Monoamine Oxidase B in the Prefrontal Cortex of Major Depressive Disorder
- 3 Anti-Inflammatory Therapeutic Potential
- 4 Availability and Access
- 5 Sources
¶ Effectiveness
Two MAOI's, Parnate and Nardil, are at the top of a weighted aggregation of patient Antidepressant Reviews for depression.
Two MAOIs, Parnate, and Nardil, are at the top of a weighted aggregation of patient Antidepressant Reviews for depression.
Source: SlateStarCodex
¶ Monoamine Oxidase B in the Prefrontal Cortex of Major Depressive Disorder
MAO-B distribution volume was significantly elevated in the prefrontal cortex of patients with major depressive episodes compared with healthy controls. Duration of illness was significantly and positively correlated with MAO-B distribution volume in the prefrontal cortex.
¶ Anti-Inflammatory Therapeutic Potential
Significant evidence supports that monoamine oxidase (MAO) inhibitor drugs have anti-inflammatory effects. MAO inhibitors are principally prescribed for the management of a variety of central nervous system (CNS)-associated diseases such as depression, Alzheimer's, and Parkinson's; however, they also have anti-inflammatory effects in the CNS and a variety of non-CNS tissues.
MAO inhibitors decrease the generation of end products such as hydrogen peroxide, aldehyde, and ammonium. They also inhibit biogenic amine degradation, and this increases cellular and pericellular catecholamines in a variety of immune and some non-immune cells. This decrease in end product metabolites and increase in catecholamines can play a significant role in the anti-inflammatory effects of MAO inhibitors.
¶ Availability and Access
Currently, it is very difficult for patients to obtain prescriptions for an MAOI.
Despite their high efficacy, MAOIs are excluded from the typical MDD treatment methodology.
https://maoinhibitors.com/ is an amazing resource of highly trained psychiatrists willing to prescribe to patients in the US
Here is a list of doctors that are familiar with and willing to prescribe these medications. Please click Edit above and update this list as needed.
| Name | Country | State | City |
| Dr John Cosgrove | Australia | NSW | Sydney |
| John Robinson | Australia | NSW | Sydney |
| Sathish Dayalan | Australia | NSW | Sydney |
| Nicole Melidonis | Australia | NSW | Sydney |
| Ben Mitchell | Australia | QLD | Brisbane |
| Ian Matthews | Australia | Queensland | Mapleton |
| Brian Ferry | Australia | VIC | Melbourne |
| Julian Lee | Australia | VIC | Melbourne |
| Michael Greenwood | Canada | British Columbia | Victoria |
| Catherine Boucher | Canada | New Brunswick | Dieppe |
| Anita Ramakrishna | Canada | Ontario | Toronto |
| Albana Dreshaj | Canada | Ontario | Toronto |
| Leonid Landa | Israel | Ha'Merkaz | Bnei Brak |
| Carlo Ignazio Cattaneo | Italy | NO | CAVAGLIETTO |
| Piotr Golicz | Switzerland | Zurich | Schlieren |
| Alicia Kohls | United States | AZ | Phoenix |
| Charles Portney | United States | CA | Santa Monica |
| Maria Daehler | United States | California | Palo Alto |
| Felix Raphael Toro | United States | FL | Jacksonville |
| Marcus Decarvalho | United States | FL | Jacksonville |
| Lester Moppertop | United States | Florida | North Naples |
| Gregory Haley | United States | Georgia | Scottdale |
| William Scheftner | United States | IL | Chicago |
| Yuhwen Chow | United States | IL | Chicago |
| Barry Gershuny | United States | Illinois | Northbrook |
| Rhonda Blevins | United States | KY | Lexington |
| Alex Cutler | United States | MA | Worcester |
| Albert Zachik | United States | MD | Bethesda |
| Mitchell Pulver | United States | ME | Brunswick |
| Barry Rittberg | United States | Minnesota | St. Louis Park |
| Joel S Hoffman | United States | New York | New York |
| Anand Chaturvedi | United States | OH | Akron |
| Bradley McClure | United States | Oklahoma | Tulsa |
| Stephanie Anderson | United States | online | online |
| Russle HORNING | United States | Phoenix | Phoenix |
| Robin Jarrett | United States | Texas | Dallas |
| Richard Mauroner | United States | TN | Chattanooga |
| Justin Scaffa | United States | TX | West Lake Hills |
| Nathan Currier | United States | Utah | Milcreek |
| Dr. Jon Berner | United States | Washington | Woodinville |
Feel free to click Edit and update this list as needed.
https://nardil.org/view/maoi-doctors/